If symptoms of irritation develop, the patient should be advised to notify the physician promptly. Even if symptomatic relief occurs within the first few days of treatment, the patient should be advised not to interrupt or discontinue therapy until the prescribed course of treatment is completed.ģ. This medication is not for any disorder other than that for which it is prescribed.Ģ. The patient should be instructed to use this medication as directed (including the replacement of missed doses). INFORMATION FOR THE PATIENT: Patients using this medication should receive the following information and instructions:ġ. It is recommended that KOH smears, cultures, or other diagnostic methods be used to confirm the diagnosis of cutaneous or mucocutaneous candidiasis and to rule out infection caused by other pathogens. If irritation or sensitization develops, treatment should be discontinued and appropriate measures taken as indicated. General: Nystatin cream should not be used for the treatment of systemic, oral, intravaginal or ophthalmic infections. Nystatin cream is contraindicated in patients with a history of hypersensitivity to any of their components. This cream is not indicated for systemic, oral, intravaginal or ophthalmic use. Nystatin cream is indicated in the treatment of cutaneous or mucocutaneous mycotic infections caused by Candida albicans and other susceptible Candida species. Nystatin exhibits no appreciable activity against bacteria, protozoa, or viruses. This resistance is lost when the antibiotic is removed. stellatoides) become quite resistant on treatment with nystatin and simultaneously become cross resistant to amphotericin as well. Generally, resistance to nystatin does not develop during therapy. On repeated subculturing with increasing levels of nystatin, Candida albicans does not develop resistance to nystatin. Nystatin acts by binding to sterols in the cell membrane of susceptible species resulting in a change in membrane permeability and the subsequent leakage of intracellular components. krusei, Torulopsis glabrata, Tricophyton rubrum, T. Microbiology: Nystatin is an antifungal antibiotic which is both fungistatic and fungicidal in vitro against a wide variety of yeasts and yeast-like fungi, including Candida albicans, C.
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